(4-chloro-2-methoxy-3-phenylquinolin-6-yl)(3-chlorophenyl)pyridin-3-ylmethanol trifluoroacetate

Base Information

Chemical Name:(4-chloro-2-methoxy-3-phenylquinolin-6-yl)(3-chlorophenyl)pyridin-3-ylmethanol trifluoroacetate
CAS No.:1600564-74-6
Molecular Formula:C₂HF₃O₂*C₂₈H₂₀Cl₂N₂O₂
Molecular Weight:601.409
Hs Code.:

Synonyms:(4-chloro-2-methoxy-3-phenylquinolin-6-yl)(3-chlorophenyl)pyridin-3-ylmethanol trifluoroacetate

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Chemical Property of (4-chloro-2-methoxy-3-phenylquinolin-6-yl)(3-chlorophenyl)pyridin-3-ylmethanol trifluoroacetate

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Technology Process of (4-chloro-2-methoxy-3-phenylquinolin-6-yl)(3-chlorophenyl)pyridin-3-ylmethanol trifluoroacetate

There total 7 articles about (4-chloro-2-methoxy-3-phenylquinolin-6-yl)(3-chlorophenyl)pyridin-3-ylmethanol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1600563-76-5
(3-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(pyridin-3-yl)methanol

: 124-41-4
sodium methylate

: 76-05-1
trifluoroacetic acid

: 1600564-74-6
(4-chloro-2-methoxy-3-phenylquinolin-6-yl)(3-chlorophenyl)pyridin-3-ylmethanol trifluoroacetate

: 1600564-72-4
(3-chlorophenyl)(2,4-dimethoxy-3-phenylquinolin-6-yl)pyridin-3-ylmethanol trifluoroacetate

Guidance literature:: (3-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(pyridin-3-yl)methanol; sodium methylate; In methanol; at 82 ℃; for 24h; Sealed tube;

trifluoroacetic acid; In methanol; water; acetonitrile; Sealed tube;

Reference yield:

: 909365-96-4
6-bromo-4-hydroxy-3-phenylquinolin-2(1H)-one

: 1600564-74-6
(4-chloro-2-methoxy-3-phenylquinolin-6-yl)(3-chlorophenyl)pyridin-3-ylmethanol trifluoroacetate

: 1600564-72-4
(3-chlorophenyl)(2,4-dimethoxy-3-phenylquinolin-6-yl)pyridin-3-ylmethanol trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 3.5 h / 107 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 20 °C

3.1: methanol / 24 h / 82 °C / Sealed tube

3.2: Sealed tube

With n-butyllithium; trichlorophosphate; In tetrahydrofuran; methanol; hexane;

Reference yield:

: 452349-62-1
methyl 5-bromo-2-(2-phenylacetamido)benzoate

: 1600564-74-6
(4-chloro-2-methoxy-3-phenylquinolin-6-yl)(3-chlorophenyl)pyridin-3-ylmethanol trifluoroacetate

: 1600564-72-4
(3-chlorophenyl)(2,4-dimethoxy-3-phenylquinolin-6-yl)pyridin-3-ylmethanol trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane; water / 4 h / -78 - 20 °C

2.1: trichlorophosphate / 3.5 h / 107 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C

3.2: 20 °C

4.1: methanol / 24 h / 82 °C / Sealed tube

4.2: Sealed tube

With n-butyllithium; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; hexane; water;