5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

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Chemical Name:5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid
CAS No.:1373274-76-0
Molecular Formula:C₂₂H₁₈FN₃O₃S
Molecular Weight:423.468
Hs Code.:

Synonyms:5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

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Chemical Property of 5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

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Technology Process of 5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

There total 9 articles about 5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1373278-21-7
tert-butyl 5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoate

: 1373274-76-0
5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 1373278-11-5
2-(5-tert-butoxy-5-oxopentyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid

: 1373274-76-0
5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium chloride / dichloromethane / 20 h / 20 °C

2.1: Lawessons reagent / toluene / 1 h / 110 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran / 18 h / 20 - 45 °C

3.2: 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h

With Lawessons reagent; sodium hydrogencarbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1195-45-5
para-fluorophenyl isocyanate

: 1373274-76-0
5-(3-(4-fluorophenyl)-4-oxo-7-(thiazol-2-yl)-3,4-dihydroquinazolin-2-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

3.2: 16 h / 60 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium chloride / dichloromethane / 20 h / 20 °C

6.1: Lawessons reagent / toluene / 1 h / 110 °C

7.1: sodium hydrogencarbonate / tetrahydrofuran / 18 h / 20 - 45 °C

7.2: 0 - 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h

With Lawessons reagent; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; ammonium chloride; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;