1-(4-fluorophenyl)-4-<4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoyl>piperazine

Base Information

Chemical Name:1-(4-fluorophenyl)-4-<4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoyl>piperazine
CAS No.:98859-09-7
Molecular Formula:C₂₇H₂₂F₄N₄O
Molecular Weight:494.491
Hs Code.:

Synonyms:1-(4-fluorophenyl)-4-<4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoyl>piperazine

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Chemical Property of 1-(4-fluorophenyl)-4-<4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoyl>piperazine

Chemical Property:

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Technology Process of 1-(4-fluorophenyl)-4-<4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoyl>piperazine

There total 4 articles about 1-(4-fluorophenyl)-4-<4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoyl>piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 346-55-4
4-chloro-7-trifluoromethyl quinoline

: 98859-16-6
1-(4-aminobenzoyl)-4-(4-fluorophenyl)piperazine

: 98859-09-7
1-(4-fluorophenyl)-4-<4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoyl>piperazine

Guidance literature:: With hydrogenchloride; In ethylene glycol; at 100 ℃; for 24h;
DOI:10.1021/jm00151a021

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 98859-09-7
1-(4-fluorophenyl)-4-<4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoyl>piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 43.9 g / triethylamine / CH₂Cl₂ / 17 h

2: 17.49 g / TiCl₃ / H₂O

3: 62 percent / conc. aq. HCl / ethane-1,2-diol / 24 h / 100 °C

With hydrogenchloride; titanium(III) chloride; triethylamine; In dichloromethane; water; ethylene glycol;
DOI:10.1021/jm00151a021

Reference yield:

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 98859-09-7
1-(4-fluorophenyl)-4-<4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoyl>piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 43.9 g / triethylamine / CH₂Cl₂ / 17 h

2: 17.49 g / TiCl₃ / H₂O

3: 62 percent / conc. aq. HCl / ethane-1,2-diol / 24 h / 100 °C

With hydrogenchloride; titanium(III) chloride; triethylamine; In dichloromethane; water; ethylene glycol;
DOI:10.1021/jm00151a021