N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)

Base Information

Chemical Name:N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)
CAS No.:1436870-30-2
Molecular Formula:C₂₄H₂₈F₂N₆O₂
Molecular Weight:470.522
Hs Code.:

Synonyms:N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)

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Chemical Property of N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)

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Technology Process of N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)

There total 4 articles about N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 138609-27-5
2,4-bis(pivaloylamino)-6-bromopyrido<2,3-d>pyrimidine

: 138563-58-3
2,5-difluoro-N-methylaniline

: 1436870-30-2
N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; In toluene; at 100 ℃; for 20h; Sealed tube;
DOI:10.1021/jm400086g

Reference yield:

: 152941-69-0
2,4-diamino-6-bromopyrido<2,3-d>pyrimidine

: 1436870-30-2
N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 8 h / Reflux

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 20 h / 100 °C / Sealed tube

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; In toluene; 2: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm400086g

Reference yield:

: 367-30-6
2,5-difluoroaniline

: 1436870-30-2
N,N′-{6-[(2,5-difluorophenyl)(methyl)amino]pyrido[2,3-d]-pyrimidine-2,4-diyl}bis(2,2-dimethylpropanamide)

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 5 h / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / Reflux

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 20 h / 100 °C / Sealed tube

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium methylate; lithium hexamethyldisilazane; In methanol; toluene; 3: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm400086g