2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-((methylsulfonyl)methyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

Base Information

Chemical Name:2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-((methylsulfonyl)methyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide
CAS No.:1582261-87-7
Molecular Formula:C₁₈H₁₉Cl₂FN₂O₄S
Molecular Weight:449.33
Hs Code.:

Synonyms:2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-((methylsulfonyl)methyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

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Chemical Property of 2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-((methylsulfonyl)methyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

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Technology Process of 2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-((methylsulfonyl)methyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

There total 4 articles about 2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-((methylsulfonyl)methyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582262-83-6
2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone

: 20277-69-4
sodium methansulfinate

: 1582261-87-7
2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-((methylsulfonyl)methyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

Guidance literature:: 2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone; sodium methansulfinate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1454906-80-9
2,2-dichloro-1-((4S,5R)-4-(fluoromethyl)-5-(4-(6-(hydroxymethyl)pyridin-3-yl)phenyl)-2,2-dimethyloxazolidin-3-yl)ethanone

: 1582261-87-7
2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-((methylsulfonyl)methyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 20 °C / Cooling with ice

2.1: N,N-dimethyl-formamide / 1 h / 60 °C

2.2: 3 h / 20 °C

With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 913835-98-0
[6-(hydroxymethyl)pyridin-3-yl]boronic acid

: 1582261-87-7
2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-((methylsulfonyl)methyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 6 h / 80 °C / Inert atmosphere; Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 20 °C / Cooling with ice

3.1: N,N-dimethyl-formamide / 1 h / 60 °C

3.2: 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;