2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone

Base Information

Chemical Name:2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone
CAS No.:1582262-83-6
Molecular Formula:C₂₀H₂₀Cl₃FN₂O₂
Molecular Weight:445.748
Hs Code.:

Synonyms:2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone

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Chemical Property of 2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone

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Technology Process of 2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone

There total 3 articles about 2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454906-80-9
2,2-dichloro-1-((4S,5R)-4-(fluoromethyl)-5-(4-(6-(hydroxymethyl)pyridin-3-yl)phenyl)-2,2-dimethyloxazolidin-3-yl)ethanone

: 1582262-83-6
2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone

Guidance literature:: With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

: 913835-98-0
[6-(hydroxymethyl)pyridin-3-yl]boronic acid

: 1582262-83-6
2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 6 h / 80 °C / Inert atmosphere; Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1431551-97-1
2,2-dichloro-1-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)ethanone

: 1582262-83-6
2,2-dichloro-1-((4S,5R)-5-(4-(6-(chloromethyl)pyridin-3-yl)phenyl)-4 (fluoromethyl)-2,2-dimethyloxazolidin-3-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 6 h / 80 °C / Inert atmosphere; Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;