6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

Base Information

• Chemical Name: 6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine
• CAS No.: 1220116-48-2
• Molecular Formula: C₃₁H₄₇N₇O₄Si₂
• Molecular Weight: 637.93

Synonyms:6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

Chemical Property of 6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

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Technology Process of 6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

There total 1 articles about 6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-azido-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine (1220116-30-2) + 4-methoxyphenylacetylen (768-60-5) → 6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine (1220116-48-2)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In dichloromethane; water; at 20 ℃; for 4h; regioselective reaction;

DOI:10.1021/jo902342z

Reference yield: 83.0%

6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine (1220116-48-2) → 6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-(2-deoxy-β-D-ribofuranosyl)purine (1220116-62-0)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 20 ℃; for 34h;

DOI:10.1021/jo902342z

upstream raw materials:

6-azido-9-[2-deoxy-3,5-di-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]purine

4-methoxyphenylacetylen

Downstream raw materials:

6-[4-(4-methoxyphenyl)-1,2,3-triazol-1-yl]-9-(2-deoxy-β-D-ribofuranosyl)purine

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