2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

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Chemical Name:2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester
CAS No.:667900-56-3
Molecular Formula:C₆₁H₇₃N₉O₁₄
Molecular Weight:1156.3
Hs Code.:

2-[2-(5-<i>tert</i>-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1<i>H</i>-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

Synonyms:2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

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Chemical Property of 2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

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Technology Process of 2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

There total 1 articles about 2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

: 24424-99-5
di-tert-butyl dicarbonate

: 667900-55-2
(S)-2-[(R)-2-((S)-5-Amino-2-{(S)-2-[(S)-2-[(S)-3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

: 667900-56-3
2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1002/ejoc.200300477

Reference yield: 87.0%

: 75-65-0
tert-butyl alcohol

: 667900-56-3
2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

: 667900-57-4
2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-tert-butoxycarbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

Guidance literature:: With dmap; 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/ejoc.200300477

Reference yield:

: 667900-56-3
2-[2-(5-tert-butoxycarbonylamino-2-{2-[2-[3-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyrylamino}-pentanoylamino)-3-phenyl-propionylamino]-succinamic acid allyl ester

: cyclic(L-valyl-L-ornithyl-D-phenylalanyl-L-asparaginyl-L-aspartyl-L-tryptophanyl)

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / DCC; 1-hydroxy-7-azabenzotriazole; DMAP / tetrahydrofuran / 20 °C

2.1: Pd(PPh₃)4; PhSiH₃ / CHCl₃ / 2 h

3.1: DCC; 1-hydroxy-7-azabenzotriazole; DMAP / tetrahydrofuran / 2 h

4.1: N-methylpyrrolidine / CH₂Cl₂ / 11 h / 20 °C

4.2: Et₃SiH; CF₃COOH / CH₂Cl₂ / 20 °C

With 1-Methylpyrrolidine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; phenylsilane; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1002/ejoc.200300477