ethyl (S)-3-(2-((S)-4-(4-cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate

Base Information

Chemical Name:ethyl (S)-3-(2-((S)-4-(4-cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate
CAS No.:186183-15-3
Molecular Formula:C₂₄H₂₄N₄O₅
Molecular Weight:448.478
Hs Code.:

Synonyms:ethyl (S)-3-(2-((S)-4-(4-cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate

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Chemical Property of ethyl (S)-3-(2-((S)-4-(4-cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate

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Technology Process of ethyl (S)-3-(2-((S)-4-(4-cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate

There total 4 articles about ethyl (S)-3-(2-((S)-4-(4-cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 184426-81-1
2-((S)-4-(4-Cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid

: 340188-50-3
ethyl (S)-3-amino-3-phenyl-propionate hydrochloride

: 186183-15-3
ethyl (S)-3-(2-((S)-4-(4-cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate

Guidance literature:: With N-ethylmorpholine;; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 184427-38-1
2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid

: 186183-15-3
ethyl (S)-3-(2-((S)-4-(4-cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / dimethylformamide / 20 h / Heating

2: 85 percent / N-ethylmorpholine, O-((cyano-ethoxycarbonylmethylen)amino)-N,N,N',N'-tetramethyluroniumtetrafluoroborate / ethyl acetate / 2 h / 20 °C

With N-ethylmorpholine;; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 184427-34-7
(S)-2-amino-2-(4-bromophenyl)-propionic acid ethyl ester

: 186183-15-3
ethyl (S)-3-(2-((S)-4-(4-cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / CH₂Cl₂ / 2 h / 0 °C

2: 78 percent / conc. HCl / 10 h / Heating

3: 95 percent / dimethylformamide / 20 h / Heating

4: 85 percent / N-ethylmorpholine, O-((cyano-ethoxycarbonylmethylen)amino)-N,N,N',N'-tetramethyluroniumtetrafluoroborate / ethyl acetate / 2 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;