9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine

Base Information

Chemical Name:9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine
CAS No.:328378-39-8
Molecular Formula:C₃₃H₃₀N₄O₆
Molecular Weight:578.624
Hs Code.:

Synonyms:9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine

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Chemical Property of 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine

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Technology Process of 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine

There total 5 articles about 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 5720-07-0
4-methoxyphenylboronic acid

: 91713-46-1
6-Chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine

: 328378-39-8
9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 8h;
DOI:10.1135/cccc20001683

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 328378-31-0
6-(4-methoxyphenyl)-9H-purine

: 328378-39-8
9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine

: C₃₃H₃₀N₄O₆

Guidance literature:: With sodium hydride; In acetonitrile; at 70 ℃; for 0.5h; Title compound not separated from byproducts;
DOI:10.1135/cccc20001683

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 328378-39-8
9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-methoxyphenyl)purine

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / Pd(PPh₃)4; K₂CO₃ / toluene / 8 h / 100 °C

2: 89 percent / Dowex 50X₈(H+) / aq. methanol / 1 h / Heating

3: NaH / acetonitrile / 0.5 h / 70 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Dowex 50X₈(H+); sodium hydride; potassium carbonate; In methanol; toluene; acetonitrile;
DOI:10.1135/cccc20001683