Carbonic acid 11-[((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)-amino]-undecyl ester 4-nitro-phenyl ester

Base Information

• Chemical Name: Carbonic acid 11-[((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)-amino]-undecyl ester 4-nitro-phenyl ester
• CAS No.: 218782-88-8
• Molecular Formula: C₃₉H₅₃FN₂O₉
• Molecular Weight: 712.856

Synonyms:Carbonic acid 11-[((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)-amino]-undecyl ester 4-nitro-phenyl ester

Chemical Property of Carbonic acid 11-[((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)-amino]-undecyl ester 4-nitro-phenyl ester

Chemical Property:

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Technology Process of Carbonic acid 11-[((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)-amino]-undecyl ester 4-nitro-phenyl ester

There total 3 articles about Carbonic acid 11-[((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)-amino]-undecyl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-Nitrophenyl chloroformate (7693-46-1) + (8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid (11-hydroxy-undecyl)-amide (218782-87-7) → Carbonic acid 11-[((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)-amino]-undecyl ester 4-nitro-phenyl ester (218782-88-8)

Guidance literature:

With pyridine; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1021/ja981846u

Reference yield:

11-aminoundecan-1-ol (27780-89-8) → Carbonic acid 11-[((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)-amino]-undecyl ester 4-nitro-phenyl ester (218782-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / HOBT, Et₃N, EDCl / CH₂Cl₂ / 2.5 h / 0 °C

2: 47 percent / pyridine / CH₂Cl₂ / 1 h / 25 °C

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1021/ja981846u

Reference yield:

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid (37927-01-8) → Carbonic acid 11-[((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)-amino]-undecyl ester 4-nitro-phenyl ester (218782-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / HOBT, Et₃N, EDCl / CH₂Cl₂ / 2.5 h / 0 °C

2: 47 percent / pyridine / CH₂Cl₂ / 1 h / 25 °C

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1021/ja981846u

upstream raw materials:

4-Nitrophenyl chloroformate

(8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid (11-hydroxy-undecyl)-amide

11-aminoundecan-1-ol

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid

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