(3,4-dichlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Base Information

Chemical Name:(3,4-dichlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester
CAS No.:1620738-97-7
Molecular Formula:C₂₉H₂₀Cl₂N₂O₃S
Molecular Weight:547.461
Hs Code.:

Synonyms:(3,4-dichlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

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Chemical Property of (3,4-dichlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Chemical Property:

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Technology Process of (3,4-dichlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

There total 6 articles about (3,4-dichlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1613219-39-8
7-(4-phenylthiazol-2-yl)-naphthalene-2-carboxylic acid

: 1078611-21-8,2682097-42-1
methyl 2-amino-2-(3,4-dichlorophenyl)acetate hydrochloride

: 1620738-97-7
(3,4-dichlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethyl acetate; at 70 ℃; for 20h;

Reference yield:

: 5043-14-1
7-bromonaphthalene-2-carboxylic acid

: 1620738-97-7
(3,4-dichlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 18 h / Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

4: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

5: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / tetrahydrofuran; ethyl acetate / 20 h / 70 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium acetate; water; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; 3: |Suzuki Coupling;

Reference yield:

: 58556-75-5
2,7-dibromonaphthalene

: 1620738-97-7
(3,4-dichlorophenyl)-{[7-(4-phenylthiazol-2-yl)naphthalene-2-carbonyl]amino}acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -76 °C

1.2: -76 - 20 °C

2.1: sulfuric acid / 18 h / Reflux

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

5.1: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

6.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / tetrahydrofuran; ethyl acetate / 20 h / 70 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sulfuric acid; potassium acetate; water; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; ethyl acetate; 4.1: |Suzuki Coupling;