1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-chloro-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate

Base Information

• Chemical Name: 1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-chloro-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate
• CAS No.: 1376607-66-7
• Molecular Formula: C₂₈H₂₉ClN₂O₇
• Molecular Weight: 541
• Mol file: 1376607-66-7.mol

Synonyms:1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-chloro-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate

Chemical Property of 1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-chloro-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-chloro-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate

There total 2 articles about 1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-chloro-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

C17H18ClNO5 + ethyl phenylcyanoacetate (4553-07-5) → 1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-chloro-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate (1376607-66-7) + 1-tert-butyl 4′,5′-diethyl 5-chloro 2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate

Guidance literature:

With C₂₉H₂₈F₆N₄OS; In toluene; at 23 ℃; for 2h; stereoselective reaction;

DOI:10.3998/ark.5550190.p008.401

Reference yield: 62.0%

C17H18ClNO5 + ethyl α-phenylisocyanoacetate (39533-31-8) → 1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-chloro-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate (1376607-66-7) + (3R,4'S,5'S)-1-tert-butyl 4',5'-diethyl 5-chloro-2-oxo-5'-phenyl-4',5'-dihydrospiro[indoline-3,3'-pyrrole]-1,4',5'-tricarboxylate (1376607-19-0)

Guidance literature:

With C₂₉H₂₈F₆N₄OS; In chloroform; at -20 ℃; for 22h; optical yield given as %ee; stereoselective reaction; Molecular sieve;

DOI:10.1039/c2cc30746d

upstream raw materials:

ethyl α-phenylisocyanoacetate

ethyl phenylcyanoacetate