39533-31-8

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 21960-10-1 ethyl 2-((diethoxyphosphoryl)oxy)-2-phenylacetate 
• 59410-82-1 (S)-α-phenylglycine ethyl ester hydrochloride 
• 88333-03-3 Benzyl isocyanide 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 34619-55-1 5-ethoxy-4-phenyloxazole 
• 6097-58-1 ethyl 2-phenyl-2-aminoacetate 
• 1039024-80-0 (2R,3R)-ethyl 3-(naphthalen-1-yl)-4-nitro-2-phenyl-2,3-dihydro-1H-pyrrole-2-carboxylate 
• 1092576-40-3 (2S,3S)-ethyl 3-(naphthalen-1-yl)-4-nitro-2-phenyl-2,3-dihydro-1H-pyrrole-2-carboxylate 
• 1376607-65-6 1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-methyl-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate 
• 1376607-17-8 (3R,4'S,5'S)-1-tert-butyl 4',5'-diethyl 5-methyl-2-oxo-5'-phenyl-4',5'-dihydrospiro[indoline-3,3'-pyrrole]-1,4',5'-tricarboxylate 
• 1376607-66-7 1-tert-butyl 4′,5′-diethyl (3R,4′S,5′R)-5-chloro-2-oxo-5′-phenyl-4′,5′-dihydrospiro[indoline-3,3′-pyrrole]-1,4′,5′-tricarboxylate 
• 1376607-19-0 (3R,4'S,5'S)-1-tert-butyl 4',5'-diethyl 5-chloro-2-oxo-5'-phenyl-4',5'-dihydrospiro[indoline-3,3'-pyrrole]-1,4',5'-tricarboxylate 
• 1376606-70-0 (3R,4'S,5'R)-diethyl 2-oxo-5'-phenyl-1-(phenylcarbamoyl)-4',5'-dihydrospiro[indoline-3,3'-pyrrole]-4',5'-dicarboxylate 
• 1376607-51-0 (3R,4'S,5'S)-diethyl 2-oxo-5'-phenyl-1-(phenylcarbamoyl)-4',5'-dihydrospiro[indoline-3,3'-pyrrole]-4',5'-dicarboxylate 
• 1376606-72-2 (3R,4'S,5'R)-diethyl-5-bromo-2-oxo-5'-phenyl-1-(phenylcarbamoyl)-4',5'-dihydrospiro-[indoline-3,3'-pyrrole]-4',5'-dicarboxylate 
• 1376607-52-1 (3R,4'S,5'S)-diethyl-5-bromo-2-oxo-5'-phenyl-1-(phenylcarbamoyl)-4',5'-dihydrospiro-[indoline-3,3'-pyrrole]-4',5'-dicarboxylate 
• 1376606-75-5 (3R,4'S,5'R)-diethyl 5-methyl-2-oxo-5'-phenyl-1-(phenylcarbamoyl)-4',5'-dihydrospiro[indoline-3,3'-pyrrole]-4',5'-dicarboxylate 
• 1376607-53-2 (3R,4'S,5'S)-diethyl 5-methyl-2-oxo-5'-phenyl-1-(phenylcarbamoyl)-4',5'-dihydrospiro[indoline-3,3'-pyrrole]-4',5'-dicarboxylate 

Relevant academic research and scientific papers

Palladium-catalyzed nucleophilic isocyanation for the synthesis of α-aryl-α-isocyanoacetoamide derivatives

α-Aryl-α-isocyanoacetoamide derivatives were synthesized through palladium-catalyzed nucleophilic isocyanation. Diethylphosphates derived from N,N-disubstituted mandelamide derivatives reacted with trimethylsilyl cyanide in the presence of a catalytic amount of Pd(OAC)2 to afford the titled isonitriles (13 examples) in moderate to high yield. The silyl cyanopalladate complex formed in situ was a proposed catalyst, which behaved as a Lewis acid promoting elimination of the phosphate group and also the N-nucleophilic cyanide reagent. The isocyanation was applied to a gram-scale reaction with 0.2 mol% of the catalyst. The obtained isocyanoacetoamide was employable for the further transformation into the trisubstituted oxazole without any purification procedure. DFT calculation suggested that the neighboring group effect of the carbonyl moiety in the substrate amide group assisted the elimination of phosphate and stabilized the carbocation intermediate. A plausible reaction mechanism of the isocyanation is also described.

Pd-catalyzed divergent C(sp2)-H Activation/Cycloimidoylation of 2-Isocyano-2,3-diarylpropanoates

A Pd-catalyzed site-selective C(sp2)-H activation/cycloimidoylation of 2-isocyano-2,3-diarylpropanoates to construct diverse cyclic imine products has been developed. Six-membered 3,4-dihydroisoquinolines containing a C3 quaternary carbon cente