2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoic acid

Base Information

Chemical Name:2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoic acid
CAS No.:1108746-18-4
Molecular Formula:C₂₀H₂₁F₆N₃O₅
Molecular Weight:497.394
Hs Code.:

Synonyms:2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoic acid

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoic acid

Chemical Property:

Boiling Point:648.0±55.0 °C(Predicted)
Density:1.487±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoic acid

There total 8 articles about 2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1108746-04-8
tert-butyl 2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoate

: 1108746-18-4
2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 942271-60-5
tert-butyl 4-fluoro-2-nitrobenzoate

: 1108746-18-4
2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 70 °C

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

4: trifluoroacetic acid; tetramethylammonium triacetoxyborohydride / dichloromethane / 16 h / 20 °C

5: triethylamine / dichloromethane / 1 h

6: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C

With palladium on activated charcoal; hydrogen; triethylamine; trifluoroacetic acid; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 942468-36-2
tert-butyl 2-nitro-4-(piperazin-1-yl)benzoate

: 1108746-18-4
2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)-4-(4-(2,2,2-trifluoroacetyl)piperazin-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

3: trifluoroacetic acid; tetramethylammonium triacetoxyborohydride / dichloromethane / 16 h / 20 °C

4: triethylamine / dichloromethane / 1 h

5: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C

With palladium on activated charcoal; hydrogen; triethylamine; trifluoroacetic acid; tetramethylammonium triacetoxyborohydride; In methanol; dichloromethane;