N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine

Base Information

Chemical Name:N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine
CAS No.:1578245-21-2
Molecular Formula:C₂₅H₂₇N₇O₂
Molecular Weight:457.535
Hs Code.:

Synonyms:N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine

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Chemical Property of N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine

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Technology Process of N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine

There total 7 articles about N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220290-68-6
2-oxa-6-azaspiro[3.4]octane hemioxalate

: 1578246-72-6
8-chloro-N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

: 1578245-21-2
N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine

Guidance literature:: With triethylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 2h;

Reference yield:

: 1578246-63-5
8-chloro-2-(methylsulfonyl)pyrido[3,4-d]pyrimidine

: 1578245-21-2
N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 - 20 °C

1.2: 18 h / 0 - 20 °C

2.1: triethylamine / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C

With sodium hydride; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; mineral oil;

Reference yield:

: 50593-92-5
5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid

: 1578245-21-2
N-(2-ethoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-oxa-6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 24 h / Reflux

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; tetrahydrofuran / 18 h / 65 °C

3.1: ammonia / methanol / 18 h / 85 °C

3.2: 2 h / 90 °C

4.1: trichlorophosphate / 18 h / 70 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 - 20 °C

6.2: 18 h / 0 - 20 °C

7.1: triethylamine / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; ammonia; sodium hydride; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; mineral oil;