Technology Process of (3S,5R,7R,11R)-1-tert-butyldiphenylsiloxy-3,5,7,11-tetramethoxy-tetradecane
There total 9 articles about (3S,5R,7R,11R)-1-tert-butyldiphenylsiloxy-3,5,7,11-tetramethoxy-tetradecane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature
2: 1.) borontrifluoride etherate, 2.) 2,2-dimethoxypropane / 1.) dichloromethane, room temperature, 14 h, 2.) dichloromethane, room temperature, 1 h
3: 80 percent / 1.6 M n-BuLi in hexane / tetrahydrofuran / 20 h / -20 °C
4: 58 percent / W-4 Raney nickel / ethanol / 6.5 h / Heating
5: 80 percent / potassium hydride in mineral oil / tetrahydrofuran / 0.83 h
With
n-butyllithium; W-4 Raney nickel; boron trifluoride diethyl etherate; potassium hydride; 2,2-dimethoxy-propane; pyridinium chlorochromate;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)89416-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) borontrifluoride etherate, 2.) 2,2-dimethoxypropane / 1.) dichloromethane, room temperature, 14 h, 2.) dichloromethane, room temperature, 1 h
2: 80 percent / 1.6 M n-BuLi in hexane / tetrahydrofuran / 20 h / -20 °C
3: 58 percent / W-4 Raney nickel / ethanol / 6.5 h / Heating
4: 80 percent / potassium hydride in mineral oil / tetrahydrofuran / 0.83 h
With
n-butyllithium; W-4 Raney nickel; boron trifluoride diethyl etherate; potassium hydride; 2,2-dimethoxy-propane;
In
tetrahydrofuran; ethanol;
DOI:10.1016/S0040-4020(01)89416-3
