Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-2-thiolate

Base Information

• Chemical Name: Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-2-thiolate
• CAS No.: 105199-41-5
• Molecular Formula: C₂₂H₂₁N₂O₃S*Na
• Molecular Weight: 416.476
• Mol file: 105199-41-5.mol

Synonyms:Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-2-thiolate

Chemical Property of Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-2-thiolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-2-thiolate

There total 1 articles about Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-2-thiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Cyanothioacetamide (7357-70-2) + ethyl (Z)-3-(4-methylphenyl)-2-benzoylpropenoate (25354-80-7) → Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-2-thiolate (105199-41-5)

Guidance literature:

With sodium methylate; In methanol; for 24h; Ambient temperature;

Reference yield: 60.0%

Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-2-thiolate (105199-41-5) → 5-Cyano-2-phenyl-6-thioxo-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester (105199-51-7)

Guidance literature:

With acetic acid; In water;

Reference yield:

Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-2-thiolate (105199-41-5) → ethyl 5-cyano-1,6-dihydro-4-(4-methylphenyl)-2-phenyl-6-thioxo-3-pyridinecarboxylate (105199-61-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / acetic acid / H₂O

2: 65 percent / nitrosylsulfuric acid / acetic acid / 1 h / 0 °C

3: 50 percent / 2-mercaptoethanol / CHCl₃ / Ambient temperature

With nitrosylsulfuric acid; acetic acid; 2-hydroxyethanethiol; In chloroform; water; acetic acid;

upstream raw materials:

Cyanothioacetamide

ethyl (Z)-3-(4-methylphenyl)-2-benzoylpropenoate

Downstream raw materials:

5-Cyano-2-phenyl-6-thioxo-4-p-tolyl-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester

ethyl 5-cyano-1,6-dihydro-4-(4-methylphenyl)-2-phenyl-6-thioxo-3-pyridinecarboxylate

C₄₄H₃₄N₄O₄S₂