3-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-imidazo[1,2-a]pyrazine

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Chemical Name:3-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-imidazo[1,2-a]pyrazine
CAS No.:1035216-25-1
Molecular Formula:C₁₈H₁₆ClN₅O₂
Molecular Weight:369.81
Hs Code.:

Synonyms:3-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-imidazo[1,2-a]pyrazine

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Chemical Property of 3-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-imidazo[1,2-a]pyrazine

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Technology Process of 3-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-imidazo[1,2-a]pyrazine

There total 3 articles about 3-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-imidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 97678-12-1
2-methylimidazo<1,2-a>pyrazine-3-carboxylic acid

: 1035216-25-1
3-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-imidazo[1,2-a]pyrazine

Guidance literature:: 2-methylimidazo<1,2-a>pyrazine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In DCE; at 20 - 40 ℃; for 0.75h;

With acetic acid; at 100 ℃; for 0.75h;

With water; sodium carbonate; In dichloromethane;

Reference yield: 25.0%

: 1035216-81-9,1035218-35-9,1311293-57-8
3-chloro-N'-hydroxy-4-isopropoxy-benzamidine

: 97678-12-1
2-methylimidazo<1,2-a>pyrazine-3-carboxylic acid

: 1035216-25-1
3-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-imidazo[1,2-a]pyrazine

Guidance literature:: 3-chloro-N'-hydroxy-4-isopropoxy-benzamidine; 2-methylimidazo<1,2-a>pyrazine-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In 1,2-dichloro-ethane; at 20 - 40 ℃; for 0.75h;

With acetic acid; at 100 ℃; for 0.75h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 87597-23-7
ethyl 2-methylimidazo<1,2-a>pyrazine-3-carboxylate

: 1035216-25-1
3-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-methyl-imidazo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water

1.2: pH 5

2.1: N-ethyl-N,N-diisopropylamine; HATU / 1,2-dichloro-ethane / 0.75 h / 20 - 40 °C

2.2: 0.75 h / 100 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,2-dichloro-ethane;