1-(2-(2-hydroxy-4-p-tolylbut-3-ynyl)-1-methyl-1H-indol-3-yl)-2-methylpropan-1-one

Base Information

Chemical Name:1-(2-(2-hydroxy-4-p-tolylbut-3-ynyl)-1-methyl-1H-indol-3-yl)-2-methylpropan-1-one
CAS No.:1314146-59-2
Molecular Formula:C₂₄H₂₅NO₂
Molecular Weight:359.468
Hs Code.:

Synonyms:1-(2-(2-hydroxy-4-p-tolylbut-3-ynyl)-1-methyl-1H-indol-3-yl)-2-methylpropan-1-one

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Chemical Property of 1-(2-(2-hydroxy-4-p-tolylbut-3-ynyl)-1-methyl-1H-indol-3-yl)-2-methylpropan-1-one

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Technology Process of 1-(2-(2-hydroxy-4-p-tolylbut-3-ynyl)-1-methyl-1H-indol-3-yl)-2-methylpropan-1-one

There total 2 articles about 1-(2-(2-hydroxy-4-p-tolylbut-3-ynyl)-1-methyl-1H-indol-3-yl)-2-methylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 57642-08-7
1-(1,2-dimethyl-1H-indol-3-yl)-2-methylpropan-1-one

: 73057-40-6
3-(4-methylphenyl)prop-2-ynal

: 1314146-59-2
1-(2-(2-hydroxy-4-p-tolylbut-3-ynyl)-1-methyl-1H-indol-3-yl)-2-methylpropan-1-one

Guidance literature:: 1-(1,2-dimethyl-1H-indol-3-yl)-2-methylpropan-1-one; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h; Inert atmosphere;

3-(4-methylphenyl)prop-2-ynal; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol2012154

Reference yield:

: 875-79-6
1,2-dimethylindole

: 1314146-59-2
1-(2-(2-hydroxy-4-p-tolylbut-3-ynyl)-1-methyl-1H-indol-3-yl)-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylaluminium chloride / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.67 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With diethylaluminium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol2012154

Reference yield: 86.0%

: 1314146-59-2
1-(2-(2-hydroxy-4-p-tolylbut-3-ynyl)-1-methyl-1H-indol-3-yl)-2-methylpropan-1-one

: 1314146-24-1
9-methyl-4-p-tolyl-9H-carbazole

Guidance literature:: With [tris(para(trifluoromethyl)phenyl)phosphine]gold(I) chloride; silver trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; at 60 ℃; Inert atmosphere; Sealed flask;
DOI:10.1021/ol2012154