dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate

Base Information

• Chemical Name: dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate
• CAS No.: 97746-09-3
• Molecular Formula: C₂₄H₂₂N₂O₆
• Molecular Weight: 434.448
• Mol file: 97746-09-3.mol

Synonyms:dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate

Chemical Property of dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate

There total 5 articles about dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-[(methoxycarbonyl)methylidene]piperidinium chloride (67067-86-1) + (1R,2S,10bR)-3-Phenyl-1,2,3,10b-tetrahydro-pyrazolo[5,1-a]isoquinoline-1,2-dicarboxylic acid dimethyl ester → dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate (97746-09-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/1522-2675(20000906)83:9<2363::AID-HLCA2363>3.0.CO;2-4

Reference yield: 60.0%

(1R,2S,10bR)-3-Phenyl-1,2,3,10b-tetrahydro-pyrazolo[5,1-a]isoquinoline-1,2-dicarboxylic acid dimethyl ester + dimethyl 2-anilino-3-(isoquinolin-1-yl)succinate (316790-99-5) → methyl 2-(isoquinolin-1-yl)acetate (69582-93-0) + dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate (97746-09-3)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/1522-2675(20000906)83:9<2363::AID-HLCA2363>3.0.CO;2-4

Reference yield: 50.0%

Methyl glyoxylate (922-68-9) + (1R,2S,10bR)-3-Phenyl-1,2,3,10b-tetrahydro-pyrazolo[5,1-a]isoquinoline-1,2-dicarboxylic acid dimethyl ester → dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate (97746-09-3)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/1522-2675(20000906)83:9<2363::AID-HLCA2363>3.0.CO;2-4

upstream raw materials:

Methyl glyoxylate

N-[(methoxycarbonyl)methylidene]piperidinium chloride

dimethyl 2-anilino-3-(isoquinolin-1-yl)succinate

dimethyl cis-but-2-ene-1,4-dioate