n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine

Base Information

Chemical Name:n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine
CAS No.:398460-95-2
Molecular Formula:C₂₆H₃₅N₃O₇
Molecular Weight:501.58
Hs Code.:

Synonyms:n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine

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Chemical Property of n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine

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Technology Process of n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine

There total 5 articles about n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 398460-93-0
ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucylglycine ethyl ester

: 398460-95-2
n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 2h;
DOI:10.3987/COM-01-9338

Reference yield:

: 61049-69-2
3-O-benzylmaltol

: 398460-95-2
n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / ethanol / 96 h / 20 °C

2: 37 percent / dioxane; H₂O / 56 h / 0 - 20 °C

3: 75 percent / N-methylmorpholine; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 72 h / 20 °C

4: 94 percent / aq. NaOH / methanol / 2 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water;
DOI:10.3987/COM-01-9338

Reference yield:

: 657-27-2,10098-89-2,26124-78-7
L-Lysine hydrochloride

: 398460-95-2
n-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / ethanol / 96 h / 20 °C

2: 37 percent / dioxane; H₂O / 56 h / 0 - 20 °C

3: 75 percent / N-methylmorpholine; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 72 h / 20 °C

4: 94 percent / aq. NaOH / methanol / 2 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water;
DOI:10.3987/COM-01-9338