ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine

Base Information

• Chemical Name: ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine
• CAS No.: 398460-92-9
• Molecular Formula: C₂₄H₃₂N₂O₆
• Molecular Weight: 444.528
• Mol file: 398460-92-9.mol

Synonyms:ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine

Chemical Property of ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine

There total 3 articles about ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

di-tert-butyl dicarbonate (24424-99-5) + ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucine sodium salt → ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine (398460-92-9)

Guidance literature:

In 1,4-dioxane; water; at 0 - 20 ℃; for 56h;

DOI:10.3987/COM-01-9338

Reference yield:

3-O-benzylmaltol (61049-69-2) → ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine (398460-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / ethanol / 96 h / 20 °C

2: 37 percent / dioxane; H₂O / 56 h / 0 - 20 °C

With sodium hydroxide; In 1,4-dioxane; ethanol; water;

DOI:10.3987/COM-01-9338

Reference yield:

L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) → ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-N-tert-butoxycarbonyl-L-norleucine (398460-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / ethanol / 96 h / 20 °C

2: 37 percent / dioxane; H₂O / 56 h / 0 - 20 °C

With sodium hydroxide; In 1,4-dioxane; ethanol; water;

DOI:10.3987/COM-01-9338

upstream raw materials:

di-tert-butyl dicarbonate

3-O-benzylmaltol

L-Lysine hydrochloride

Downstream raw materials:

N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine...

C₇₁H₉₁N₉O₁₅

N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucylglycine ethyl ester

N-tert-butoxycarbonyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanyl-ε-(3-benzyloxy-1,4-dihydro-2-methyl-4-oxo-1-pyridyl)-L-norleucyl-β-alanine ethyl ester