N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-2-chloro-6-fluoro-N-(2-hydroxyethyl)-3-methoxybenzamide

Base Information

Chemical Name:N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-2-chloro-6-fluoro-N-(2-hydroxyethyl)-3-methoxybenzamide
CAS No.:1616290-35-7
Molecular Formula:C₂₅H₂₆ClFN₂O₄
Molecular Weight:472.944
Hs Code.:

Synonyms:N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-2-chloro-6-fluoro-N-(2-hydroxyethyl)-3-methoxybenzamide

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Chemical Property of N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-2-chloro-6-fluoro-N-(2-hydroxyethyl)-3-methoxybenzamide

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Technology Process of N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-2-chloro-6-fluoro-N-(2-hydroxyethyl)-3-methoxybenzamide

There total 6 articles about N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-2-chloro-6-fluoro-N-(2-hydroxyethyl)-3-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 886499-40-7
2-chloro-6-fluoro-3-methoxy-benzoic acid

: 1616288-89-1
2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol

: 1616290-35-7
N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-2-chloro-6-fluoro-N-(2-hydroxyethyl)-3-methoxybenzamide

Guidance literature:: 2-chloro-6-fluoro-3-methoxy-benzoic acid; With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.0833333h;

2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 769-28-8,70254-47-6
2-hydroxy-4,6-dimethyl-3-carbonitrile

: 1616290-35-7
N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-2-chloro-6-fluoro-N-(2-hydroxyethyl)-3-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver(l) oxide / toluene / 20 h / 110 °C

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

3.1: methanol / 1 h / 20 °C

4.1: methanol; sodium cyanoborohydride / 0 - 20 °C

5.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h

5.2: 2 h / 20 °C

With methanol; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; silver(l) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 53475-53-9
2-(benzyloxy)-4,6-dimethylpyridine-3-carbonitrile

: 1616290-35-7
N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-2-chloro-6-fluoro-N-(2-hydroxyethyl)-3-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

2.1: methanol / 1 h / 20 °C

3.1: methanol; sodium cyanoborohydride / 0 - 20 °C

4.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h

4.2: 2 h / 20 °C

With methanol; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;