2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol

Base Information

• Chemical Name: 2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol
• CAS No.: 1616288-89-1
• Molecular Formula: C₁₇H₂₂N₂O₂
• Molecular Weight: 286.374
• Mol file: 1616288-89-1.mol

Synonyms:2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol

Chemical Property of 2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol

Chemical Property:

• Boiling Point: 462.7±40.0 °C(Predicted)
• Density: 1.120±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol

There total 6 articles about 2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde (721959-71-3) + ethanolamine (141-43-5) → 2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol (1616288-89-1)

Guidance literature:

2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde; ethanolamine; In methanol; at 20 ℃; for 1h; Inert atmosphere;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00515

Reference yield:

C17H20N2O2 → 2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol (1616288-89-1)

Guidance literature:

With methanol; sodium cyanoborohydride; at 0 - 20 ℃;

Reference yield:

2-(benzyloxy)-4,6-dimethylpyridine-3-carbonitrile (53475-53-9) → 2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol (1616288-89-1)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

2: methanol / 1 h / 20 °C

3: methanol; sodium cyanoborohydride / 0 - 20 °C

With methanol; diisobutylaluminium hydride; sodium cyanoborohydride; In methanol; dichloromethane; toluene;

upstream raw materials:

2-hydroxy-4,6-dimethyl-3-carbonitrile

2-(benzyloxy)-4,6-dimethylpyridine-3-carbonitrile

2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde

ethanolamine

Downstream raw materials:

ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

N-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-3-ethoxy-6-hydroxy-N-(2-hydroxyethyl)-2-methylbenzamide

4-((2-benzyloxy-4,6-dimethylpyridin-3-yl)methyl)-6-chloro-7-methoxy-3,4-dihydrobenzo[f ][1,4]oxazepin-5(2H)-one

4-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-ethoxy-6-methyl-3,4-dihydro-1,4-benzoxazepin-5(2H)-one