(R)-tert-butyl 1-(5-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-2,2-dimethylpropylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(5-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-2,2-dimethylpropylcarbamate
CAS No.:1338780-09-8
Molecular Formula:C₂₅H₂₉F₃N₄O₂
Molecular Weight:474.526
Hs Code.:

Synonyms:(R)-tert-butyl 1-(5-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-2,2-dimethylpropylcarbamate

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Chemical Property of (R)-tert-butyl 1-(5-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-2,2-dimethylpropylcarbamate

Chemical Property:

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Technology Process of (R)-tert-butyl 1-(5-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-2,2-dimethylpropylcarbamate

There total 6 articles about (R)-tert-butyl 1-(5-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-2,2-dimethylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.2%

: 1029623-82-2
(R)-tert-butyl 1-(3-(2,5-difluorophenyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropylcarbamate

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 1338780-09-8
(R)-tert-butyl 1-(5-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-2,2-dimethylpropylcarbamate

: 1338780-08-7
(R)-tert-butyl 1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropylcarbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 64248-64-2
2,5-difluorobenzonitrile

: 1338780-09-8
(R)-tert-butyl 1-(5-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-2,2-dimethylpropylcarbamate

: 1338780-08-7
(R)-tert-butyl 1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine / ethanol / 0.5 h / 20 °C

2: triethylamine / tetrahydrofuran / -5 - 20 °C

3: xylenes / 150 °C

4: caesium carbonate / N,N-dimethyl-formamide

With caesium carbonate; triethylamine; hydrazine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; xylenes;

Reference yield:

: 1029623-74-2
(R)-tert-butyl 1-(2-((2,5-difluorophenyl)(imino)methyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

: 1338780-09-8
(R)-tert-butyl 1-(5-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-2,2-dimethylpropylcarbamate

: 1338780-08-7
(R)-tert-butyl 1-(3-(2,5-difluorophenyl)-1-(3-fluorobenzyl)-1H-1,2,4-triazol-5-yl)-2,2-dimethylpropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: xylenes / 150 °C

2: caesium carbonate / N,N-dimethyl-formamide

With caesium carbonate; In N,N-dimethyl-formamide; xylenes;