(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide

Base Information

Chemical Name:(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide
CAS No.:1380325-37-0
Molecular Formula:C₂₈H₃₃NO₂
Molecular Weight:415.576
Hs Code.:

Synonyms:(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide

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Technology Process of (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide

There total 6 articles about (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1380325-28-9
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide

: 100-39-0
benzyl bromide

: 1380325-37-0
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide; With n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 1.33333h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; hexane; at 0 ℃; for 1.3h; optical yield given as %de; Inert atmosphere;
DOI:10.1002/anie.201200370

Reference yield:

: 301191-47-9
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]formamide

: 1380325-37-0
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere

2.1: tetrahydrofuran / 1.5 h / 23 °C / Inert atmosphere

3.1: n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride / tetrahydrofuran; hexane / 1.33 h / -78 - 23 °C / Inert atmosphere

3.2: 1.3 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1002/anie.201200370

Reference yield:

: 530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0
(1S,2S)-2-amino-1,2-diphenylethanol

: 1380325-37-0
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylhexanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; diethyl ether / 2.5 h / -40 - 23 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere

3.1: tetrahydrofuran / 1.5 h / 23 °C / Inert atmosphere

4.1: n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride / tetrahydrofuran; hexane / 1.33 h / -78 - 23 °C / Inert atmosphere

4.2: 1.3 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1002/anie.201200370