7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

Base Information

Chemical Name:7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride
CAS No.:1352144-58-1
Molecular Formula:C₂₀H₁₆ClF₃N₂*ClH
Molecular Weight:413.27
Hs Code.:

Synonyms:7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

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Chemical Property of 7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

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Technology Process of 7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

There total 6 articles about 7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 55805-22-6
4-(1,1-difluoroethyl)benzaldehyde

: 1352144-77-4
C₁₁H₁₀ClFN₂*ClH

: 1352144-58-1
7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

Guidance literature:: In ethanol; for 4h; Reflux;

Reference yield:

: 1253789-92-2
C₇H₄ClFN₂

: 1352144-58-1
7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 6 h / Reflux

2.1: dimethylsulfide borane complex / tetrahydrofuran / Inert atmosphere; Reflux

2.2: Cooling with ice; Reflux

3.1: ethanol / 4 h / Reflux

With dimethylsulfide borane complex; acetic acid; In tetrahydrofuran; ethanol;

Reference yield:

: 153505-32-9
2-chloro-4-fluoro-6-nitro-benzenamine

: 1352144-58-1
7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butylnitrite / acetonitrile / 0.25 h / 70 °C

1.2: 70 °C

2.1: acetic acid; iron / 1 h / 70 °C

3.1: acetic acid / 6 h / Reflux

4.1: dimethylsulfide borane complex / tetrahydrofuran / Inert atmosphere; Reflux

4.2: Cooling with ice; Reflux

5.1: ethanol / 4 h / Reflux

With tert.-butylnitrite; dimethylsulfide borane complex; iron; acetic acid; In tetrahydrofuran; ethanol; acetonitrile;