55805-22-6

Usage

Uses

Used in Chemical and Pharmaceutical Production:
4-(1,1-difluoroethyl)benzaldehyde is utilized as an intermediate in the synthesis of various chemicals and pharmaceuticals, contributing to the development of new compounds with potential therapeutic and industrial applications.
Used in Perfumery:
In the fragrance industry, 4-(1,1-difluoroethyl)benzaldehyde is employed as a key ingredient in the creation of perfumes, capitalizing on its strong, sweet, and aromatic scent to enhance the olfactory profiles of these products.
Used in Flavorings:
4-(1,1-difluoroethyl)benzaldehyde also finds application in the food and beverage industry, where it is used as a flavoring agent to impart a distinctive taste and aroma to various consumer products.
Used in Organic Synthesis and Material Science:
Due to its versatile chemical reactivity and structural properties, 4-(1,1-difluoroethyl)benzaldehyde holds potential in the realms of organic synthesis and material science, where it can be used to develop novel materials and compounds with specific properties.
It is crucial to handle and store 4-(1,1-difluoroethyl)benzaldehyde with care, as it may pose risks to human health and the environment if not managed properly.

Upstream product

• 1443-80-7 4-cyanophenyl methyl ketone 
• 444915-84-8 methyl 4-(1,1-difluoroethyl)benzoate 
• 3609-53-8 methyl 4-acetylbenzoate 
• 99-90-1 para-bromoacetophenone 
• 1000994-95-5 1-bromo-4-(1,1-difluoroethyl)-benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 55805-25-9 [4-(1,1-difluoroethyl)phenyl]methanol 
• 55805-05-5 4-(1,1-difluoroethyl)benzonitrile 

Downstream Products

• 1352144-35-4 7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride 
• 1352144-58-1 7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-9-fluoro-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride 
• 1146157-06-3 4-(5-{1-[4-(1,1-difluoroethyl)benzyl]azetidin-3-yloxy}-pyridin-2-yl)-2-fluoro-N-(2-hydroxyethyl)benzamide 

Relevant academic research and scientific papers

4-Aryl Pyrrolidines as Novel Orally Efficacious Antimalarial Agents. Part 2: 2-Aryl- N-(4-arylpyrrolidin-3-yl)acetamides

Malaria is caused by infection from the Plasmodium parasite and kills hundreds of thousands of people every year. Emergence of new drug resistant strains of Plasmodium demands identification of new drugs with novel chemotypes and mechanisms of action. As

Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)

A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.

PYRROLIDINE COMPOUNDS FOR THE TREATMENT OF MALARIA

Pyrrolidine derivatives of formula I are used as anti-malaria agents, wherein the variables are as defined herein. Method of employing such agents in the treatment and prevention of malaria are also provided herein.

Gem-difluoro ethyl substitutional diphenylethene and diphenylethane derivative as well as preparation method and application thereof

The invention discloses gem-difluoro ethyl substitutional diphenylethene and diphenylethene diphenylethane derivatives as well as a preparation method and application thereof. A 4' bit of a B aromatic ring of diphenylethane/diphenylethene is subjected to chemical structure modification through gem-difluoro ethyl, and meanwhile, a 2' bit is modified into nitro or an amino group and other substituent groups; the gem-difluoro ethyl substitutional diphenylethene and diphenylethane derivative has relatively high antitumor activity in vitro, and the antitumor activity of a trans-form is better than the antitumor activity of a cis-form; with the introduction of fluorine atoms, not only is the physical property of the compound changed, but also the antitumor activity in vitro is improved at the same time, and the derivative has a relatively good inhibiting effect on multiple tumor cells.

PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I'), W, Y, R2, R3, R4, and Y4 are as described hereinabove), or pharmaceutically acceptable salts thereof.

FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE

The invention relates to thiazole compounds of Formula (I) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Process for producing fluorinated organic compounds containing a difluoromethylene group from compounds comprising at least one carbonyl function

A novel process for producing fluorinated organic compounds containing a difluoromethylene group, essentially characterized by reacting organic compounds containing a carbonyl function with molybdenum hexafluoride at room temperature and under atmospheric