4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate

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Chemical Name:4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate
CAS No.:133731-50-7
Molecular Formula:C₆₁H₅₁N₅O₇S₂
Molecular Weight:1030.24
Hs Code.:

Synonyms:4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate

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Chemical Property of 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate

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Technology Process of 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate

There total 6 articles about 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 133731-49-4
4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-tert-butyldimethylsilyloxy-1-propenyl>-3-cephem-4-carboxylate

: 133731-50-7
4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate

Guidance literature:: With hydrogenchloride; In acetone; for 2h; Ambient temperature;
DOI:10.7164/antibiotics.47.1526

Reference yield:

: para-methoxybenzyl (6R,7R)-7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride

: 133731-50-7
4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 1-hydroxybenzotriazole, DCC, 2.) Et₃N / 1.) DMF, 1 h, 2.) DMF, 18 h

2: NaI / acetone / 1 h

3: ethyl acetate / 4 h

4: 1.) 1M NaOH / 1.) CH₂Cl₂, H₂O, 20 min, 2.) CH₂Cl₂, r.t., 16 h

5: 49 percent / 1M HCl / acetone / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium iodide; In ethyl acetate; acetone;
DOI:10.7164/antibiotics.47.1526

Reference yield:

: 4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-(triphenylphosphonium)methyl-3-cephem-4-carboxylate iodide

: 133731-50-7
4-methoxyphenylmethyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-<(Z)-3-hydroxy-1-propenyl>-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1M NaOH / 1.) CH₂Cl₂, H₂O, 20 min, 2.) CH₂Cl₂, r.t., 16 h

2: 49 percent / 1M HCl / acetone / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; In acetone;
DOI:10.7164/antibiotics.47.1526