(s)-1-(3-Bromo-1,4-dimethoxy-naphthalen-2-yl)-propan-2-ol

Base Information

Chemical Name:(s)-1-(3-Bromo-1,4-dimethoxy-naphthalen-2-yl)-propan-2-ol
CAS No.:404909-58-6
Molecular Formula:C₁₅H₁₇BrO₃
Molecular Weight:325.202
Hs Code.:2909499000
DSSTox Substance ID:DTXSID00477056
Nikkaji Number:J1.687.952E
Wikidata:Q82309144
Mol file:404909-58-6.mol

Synonyms:404909-58-6;(s)-1-(3-bromo-1,4-dimethoxy-naphthalen-2-yl)-propan-2-ol;(s)-1-(3-bromo-1,4-dimethoxynaphthalen-2-yl)propan-2-ol;(2S)-1-(3-Bromo-1,4-dimethoxynaphthalen-2-yl)propan-2-ol;DTXSID00477056;(S)-1-(3-Bromo-1,4-dimethoxynaphthalen-2-yl) propan-2-ol

Suppliers and Price of (s)-1-(3-Bromo-1,4-dimethoxy-naphthalen-2-yl)-propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-1-(3-Bromo-1,4-dimethoxynaphthalen-2-yl)propan-2-ol 97%
1g
$ 1797.00

American Custom Chemicals Corporation
(S)-1-(3-BROMO-1,4-DIMETHOXY-NAPHTHALEN-2-YL)-PROPAN-2-OL 95.00%
1G
$ 1862.78

Total 3 raw suppliers

Chemical Property of (s)-1-(3-Bromo-1,4-dimethoxy-naphthalen-2-yl)-propan-2-ol

Chemical Property:

Vapor Pressure:1.91E-08mmHg at 25°C
Refractive Index:1.604
Boiling Point:438°C at 760 mmHg
Flash Point:218.7°C
PSA：38.69000
Density:1.384g/cm³
LogP:3.54280
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:324.03611
Heavy Atom Count:19
Complexity:287

Purity/Quality:: (S)-1-(3-Bromo-1,4-dimethoxynaphthalen-2-yl)propan-2-ol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=C(C2=CC=CC=C2C(=C1Br)OC)OC)O
Isomeric SMILES:C[C@@H](CC1=C(C2=CC=CC=C2C(=C1Br)OC)OC)O

Technology Process of (s)-1-(3-Bromo-1,4-dimethoxy-naphthalen-2-yl)-propan-2-ol

There total 7 articles about (s)-1-(3-Bromo-1,4-dimethoxy-naphthalen-2-yl)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 876-27-7
4-chlorophenyl acetate

: 404908-62-9
3-bromo-2-(2-hydroxypropyl)-1,4-dimethoxynaphthalene

: (-)-(R)-3-bromo-2-(2-acetoxypropyl)-1,4-dimethoxynaphthalene

: 404909-58-6
(+)-(S)-3-bromo-2-(2'-hydroxypropyl)-1,4-dimethoxynaphthalene

: 404909-82-6
(-)-(R)-3-bromo-2-(2'-hydroxypropyl)-1,4-dimethoxynaphthalene

Guidance literature:: With novozyme 435; In toluene; at 60 ℃; for 6h; microwave irradiation;
DOI:10.1016/j.tetasy.2007.06.035

Reference yield:

: 90-15-3
α-naphthol

: 404909-58-6
(+)-(S)-3-bromo-2-(2'-hydroxypropyl)-1,4-dimethoxynaphthalene

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / N-bromosuccinimide / acetic acid; H₂O / 1 h / 65 °C

2: 61 percent / methylaluminum dichloride / CH₂Cl₂ / 2 h / -78 °C

3: sodium dithionite; tetrabutylammonium iodide / tetrahydrofuran; H₂O / 0.33 h

4: 0.398 g / aqueous potassium hydroxide / tetrahydrofuran / 4 h

5: 74 percent / copper(I) chloride; oxygen / palladium(II) chloride / dimethylformamide; H₂O / 24 h / 20 °C

6: triisopropyl borate; (S)-2-(diphenylhydroxymethyl)pyrrolidine; borane-dimethyl sulfide / tetrahydrofuran / 5 h / 20 °C

With potassium hydroxide; N-Bromosuccinimide; sodium dithionite; Triisopropyl borate; (S)-diphenylprolinol; dimethylsulfide borane complex; oxygen; methylaluminum dichloride; tetra-(n-butyl)ammonium iodide; copper(l) chloride; palladium dichloride; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; 5: Wacker oxidation;
DOI:10.1016/S0040-4020(01)01120-6

Reference yield:

: 2065-37-4
2-bromo-1,4-naphthoquinone

: 404909-58-6
(+)-(S)-3-bromo-2-(2'-hydroxypropyl)-1,4-dimethoxynaphthalene

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / methylaluminum dichloride / CH₂Cl₂ / 2 h / -78 °C

2: sodium dithionite; tetrabutylammonium iodide / tetrahydrofuran; H₂O / 0.33 h

3: 0.398 g / aqueous potassium hydroxide / tetrahydrofuran / 4 h

4: 74 percent / copper(I) chloride; oxygen / palladium(II) chloride / dimethylformamide; H₂O / 24 h / 20 °C

5: triisopropyl borate; (S)-2-(diphenylhydroxymethyl)pyrrolidine; borane-dimethyl sulfide / tetrahydrofuran / 5 h / 20 °C

With potassium hydroxide; sodium dithionite; Triisopropyl borate; (S)-diphenylprolinol; dimethylsulfide borane complex; oxygen; methylaluminum dichloride; tetra-(n-butyl)ammonium iodide; copper(l) chloride; palladium dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 4: Wacker oxidation;
DOI:10.1016/S0040-4020(01)01120-6