2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzaldehyde

Base Information

Chemical Name:2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzaldehyde
CAS No.:1101146-34-2
Molecular Formula:C₂₄H₁₈N₄O₂
Molecular Weight:394.433
Hs Code.:

Synonyms:2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzaldehyde

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Chemical Property of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzaldehyde

Chemical Property:

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Technology Process of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzaldehyde

There total 4 articles about 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1101145-49-6
(2-amino-6-iodoquinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone

: 40138-16-7
2-formylbenzene boronic acid

: 1101146-34-2
2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzaldehyde

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; at 130 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 20780-76-1
5-iodoisatin

: 1101146-34-2
2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 16 h / 10 - 23 °C

2: tetrahydrofuran / 0.5 h / 25 °C

3: cesium fluoride / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 130 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; cesium fluoride; In tetrahydrofuran; ethanol; water; acetonitrile; 4: |Suzuki Coupling;

Reference yield:

: 1228311-56-5
tert-butyl 5-iodo-2,3-dioxo-2,3-dihydroindole-1-carboxylate

: 1101146-34-2
2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.5 h / 25 °C

2: cesium fluoride / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; water / 0.5 h / 130 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; cesium fluoride; In tetrahydrofuran; ethanol; water; acetonitrile; 3: |Suzuki Coupling;