Technology Process of 4-cyano-N-methoxy-N-methyl-3,5-dihexyloxybenzamide
There total 5 articles about 4-cyano-N-methoxy-N-methyl-3,5-dihexyloxybenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-cyano-3,5-dihexyloxybenzoic acid; isobutyl chloroformate;
With
4-methyl-morpholine;
In
dichloromethane;
at 0 ℃;
for 0.333333h;
With
hydroxylamine hydrochloride;
In
dichloromethane;
at 0 ℃;
for 1h;
DOI:10.1039/c3ob40452h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N-dimethyl-formamide / 48 h / 150 - 160 °C
2.1: tetrabutylammomium bromide; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h
3.1: 4-methyl-morpholine / dichloromethane / 0.33 h / 0 °C
3.2: 1 h / 0 °C
With
4-methyl-morpholine; lithium hydroxide monohydrate; tetrabutylammomium bromide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ob40452h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / 18 h / Reflux
2.1: tetrabutylammomium bromide; potassium carbonate / acetone / 18 h / Reflux
3.1: N,N-dimethyl-formamide / 48 h / 150 - 160 °C
4.1: tetrabutylammomium bromide; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 18 h
5.1: 4-methyl-morpholine / dichloromethane / 0.33 h / 0 °C
5.2: 1 h / 0 °C
With
4-methyl-morpholine; lithium hydroxide monohydrate; sulfuric acid; tetrabutylammomium bromide; potassium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
2.1: |Williamson Ether Synthesis;
DOI:10.1039/c3ob40452h
