(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1361293-97-1
Molecular Formula:C₃₆H₃₈Cl₄N₂O₆
Molecular Weight:736.52
Hs Code.:

(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate

Synonyms:(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 12 articles about (S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1361293-82-4
(S)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

: 1361293-97-1
(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; Inert atmosphere;

Reference yield:

: 1361293-50-6
(S)-3-Amino-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-hydroxybutanamide

: 1361293-97-1
(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: methanol / 50 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / 1,4-dioxane / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

4.1: sodium / toluene; methanol / 48 h / 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

5.2: 20 °C

6.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

7.1: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

7.2: 2.5 h / 55 °C / Inert atmosphere

8.1: hydrogenchloride / water; methanol / 1 h / 55 °C / Inert atmosphere

9.1: sodium hydrogencarbonate / 1,4-dioxane; water / 20 °C / Inert atmosphere

With hydrogenchloride; sodium; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1361293-51-7
(S)-methyl 3-(4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylamino)propanoate

: 1361293-97-1
(S)-tert-butyl 3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-2-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

3.1: sodium / toluene; methanol / 48 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

4.2: 20 °C

5.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

6.1: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

6.2: 2.5 h / 55 °C / Inert atmosphere

7.1: hydrogenchloride / water; methanol / 1 h / 55 °C / Inert atmosphere

8.1: sodium hydrogencarbonate / 1,4-dioxane; water / 20 °C / Inert atmosphere

With hydrogenchloride; sodium; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;