7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

Base Information

Chemical Name:7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one
CAS No.:1630951-39-1
Molecular Formula:C₂₅H₂₆N₄O
Molecular Weight:398.508
Hs Code.:

Synonyms:7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

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Chemical Property of 7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

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Technology Process of 7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

There total 11 articles about 7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1630951-30-2
7-(piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one trifluoroacetate

: 113118-84-6
5-phenyl-3-pyridinecarboxaldehyde

: 1630951-39-1
7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: 7-(piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one trifluoroacetate; 5-phenyl-3-pyridinecarboxaldehyde; With triethylamine; In dimethyl sulfoxide; at 0 - 20 ℃; for 0.5h;

With sodium triacetoxy borohydride; In dimethyl sulfoxide; for 6h;
DOI:10.2174/15734064113096660046

Reference yield: 50.0%

: 1630951-39-1
7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 0 - 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dimethyl sulfoxide; at 20 ℃; for 6h;

Reference yield:

: 591-19-5
m-Bromoaniline

: 1630951-39-1
7-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydroxylamine hydrochloride; sodium sulfate

2.1: sulfuric acid / 0.5 h / 60 °C

3.1: hydroxylamine hydrochloride / water; ethanol / 12 h

4.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 3 h / 0 °C / Cooling with ice; Reflux

4.2: 1 h / 20 - 30 °C

5.1: borane-THF / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

6.1: tetrahydrofuran / 6 h / 20 - 80 °C

7.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 14 h / 80 °C / Inert atmosphere

8.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 12 h

9.1: dichloromethane; tetrahydrofuran / 6 h / 0 - 20 °C

10.1: triethylamine / dimethyl sulfoxide / 0.5 h / 0 - 20 °C

10.2: 6 h

With 2,6-dimethylpyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; borane-THF; trifluoromethylsulfonic anhydride; sulfuric acid; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; potassium acetate; sodium sulfate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 7.1: |Suzuki-Miyaura Coupling;
DOI:10.2174/15734064113096660046