3-(chloromethyl)-α-(3,4-dimethoxyphenyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile

Base Information

Chemical Name:3-(chloromethyl)-α-(3,4-dimethoxyphenyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile
CAS No.:167159-61-7
Molecular Formula:C₂₅H₂₄ClNO₂S
Molecular Weight:437.99
Hs Code.:

Synonyms:3-(chloromethyl)-α-(3,4-dimethoxyphenyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile

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Chemical Property of 3-(chloromethyl)-α-(3,4-dimethoxyphenyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile

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Technology Process of 3-(chloromethyl)-α-(3,4-dimethoxyphenyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile

There total 5 articles about 3-(chloromethyl)-α-(3,4-dimethoxyphenyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 167159-60-6
α-(3,4-dimethoxyphenyl)-3-(hydroxymethyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile

: 167159-61-7
3-(chloromethyl)-α-(3,4-dimethoxyphenyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile

Guidance literature:: With thionyl chloride; In N,N-dimethyl-formamide; at 70 ℃; for 17h;
DOI:10.1021/jm9804477

Reference yield:

: 28750-77-8
α-chloro-3,4-dimetoxybenzeneacetonitrile

: 167159-61-7
3-(chloromethyl)-α-(3,4-dimethoxyphenyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / K₂CO₃ / acetonitrile / 12 h / 65 °C

2: 1.) n-BuLi / 1.) THF, -78 deg C, 35 min, 2.) THF, a) -78 deg C, 40 min, b) 25 deg C, 15 min

3: 52 percent / BH₃*SMe₂ / tetrahydrofuran / 18 h / 25 °C

4: 76 percent / SOCl₂ / dimethylformamide / 17 h / 70 °C

With n-butyllithium; thionyl chloride; dimethylsulfide borane complex; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm9804477

Reference yield:

: 106-45-6
para-thiocresol

: 167159-61-7
3-(chloromethyl)-α-(3,4-dimethoxyphenyl)-α-<(4-methylphenyl)thio>benzenepropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / K₂CO₃ / acetonitrile / 12 h / 65 °C

2: 1.) n-BuLi / 1.) THF, -78 deg C, 35 min, 2.) THF, a) -78 deg C, 40 min, b) 25 deg C, 15 min

3: 52 percent / BH₃*SMe₂ / tetrahydrofuran / 18 h / 25 °C

4: 76 percent / SOCl₂ / dimethylformamide / 17 h / 70 °C

With n-butyllithium; thionyl chloride; dimethylsulfide borane complex; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm9804477