17α-<(phenylseleno)ethynyl>-17β-estradiol

Base Information

• Chemical Name: 17α-<(phenylseleno)ethynyl>-17β-estradiol
• CAS No.: 83420-82-0
• Molecular Formula: C₂₆H₂₈O₂Se
• Molecular Weight: 451.467
• Mol file: 83420-82-0.mol

Synonyms:17α-<(phenylseleno)ethynyl>-17β-estradiol

Chemical Property of 17α-<(phenylseleno)ethynyl>-17β-estradiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17α-<(phenylseleno)ethynyl>-17β-estradiol

There total 4 articles about 17α-<(phenylseleno)ethynyl>-17β-estradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C36H44O4Se → 17α-<(phenylseleno)ethynyl>-17β-estradiol (83420-82-0)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; water; at 40 ℃; for 4h; Yield given;

DOI:10.1021/jm00354a019

Reference yield:

diphenyl diselenide (1666-13-3) → 17α-<(phenylseleno)ethynyl>-17β-estradiol (83420-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) hexane, ether, 25 deg C, 1 h, 2.) hexane, ether, RT, 2 h

2: p-TsOH / ethanol; H₂O / 4 h / 40 °C

With n-butyllithium; toluene-4-sulfonic acid; In ethanol; water;

DOI:10.1021/jm00354a019

Reference yield:

ethinyl estradiol (57-63-6) → 17α-<(phenylseleno)ethynyl>-17β-estradiol (83420-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / POCl₃ / tetrahydrofuran / 1 h

2: 1.) n-BuLi / 1.) hexane, ether, 25 deg C, 1 h, 2.) hexane, ether, RT, 2 h

3: p-TsOH / ethanol; H₂O / 4 h / 40 °C

With n-butyllithium; toluene-4-sulfonic acid; trichlorophosphate; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm00354a019

upstream raw materials:

diphenyl diselenide

ethinyl estradiol

17α-ethynylestra-3,17β-diol 3,17-bis(tetrahydropyranyl ether)