Technology Process of (2R,6R)-1,2-Dibenzyl-piperidine-2,6-dicarboxylic acid dimethyl ester
There total 4 articles about (2R,6R)-1,2-Dibenzyl-piperidine-2,6-dicarboxylic acid dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Dimethyl cis-N-benzyl-2,6-piperidinedicarboxylate;
With
chiral bis-lithium amide base;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
benzyl bromide;
In
tetrahydrofuran;
at -78 - 20 ℃;
DOI:10.1055/s-1999-2813
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 91 percent / H2 / Pd/C / ethanol / 10343 Torr
2.1: 86 percent / Na2CO3; H2O / CH2Cl2
3.1: chiral bis-lithium amide base / tetrahydrofuran / 1 h / -78 °C
3.2: 78 percent / tetrahydrofuran / -78 - 20 °C
With
chiral bis-lithium amide base; water; hydrogen; sodium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
1.1: Catalytic hydrogenation / 2.1: Alkylation / 3.1: Metallation / 3.2: Alkylation;
DOI:10.1055/s-1999-2813
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 75 percent / 2,2-dimethoxypropane; HCl
2.1: 91 percent / H2 / Pd/C / ethanol / 10343 Torr
3.1: 86 percent / Na2CO3; H2O / CH2Cl2
4.1: chiral bis-lithium amide base / tetrahydrofuran / 1 h / -78 °C
4.2: 78 percent / tetrahydrofuran / -78 - 20 °C
With
hydrogenchloride; chiral bis-lithium amide base; water; hydrogen; sodium carbonate; 2,2-dimethoxy-propane;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
1.1: Esterification / 2.1: Catalytic hydrogenation / 3.1: Alkylation / 4.1: Metallation / 4.2: Alkylation;
DOI:10.1055/s-1999-2813
