5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine

Base Information

Chemical Name:5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine
CAS No.:951408-28-9
Molecular Formula:C₁₁H₁₁F₂N
Molecular Weight:195.212
Hs Code.:

Synonyms:5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine

Suppliers and Price of 5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine

There total 4 articles about 5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 914801-74-4
N-(2,2-difluoro-1-phenylethylidene)isopropylamine

: 58503-62-1
1-azido-3-iodopropane

: 951408-28-9
5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine

Guidance literature:: N-(2,2-difluoro-1-phenylethylidene)isopropylamine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

1-azido-3-iodopropane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 15h;

With tin(ll) chloride; In methanol; at 20 ℃; for 5h; Further stages.;
DOI:10.1021/jo800768q

Reference yield:

: 4,4-difluoro-5-oxo-5-phenylpentanenitrile

: 951408-28-9
5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine

Guidance literature:: With raney nickel; In methanol; at 50 ℃; under 37503.8 Torr; Inert atmosphere; Flow reactor;
DOI:10.1055/s-0036-1588313

Reference yield:

: 4-cyano-2,2-difluorobutyric acid ethyl ester

: 951408-28-9
5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether; dibutyl ether / -78 °C / Inert atmosphere

2: raney nickel / methanol / 50 °C / 37503.8 Torr / Inert atmosphere; Flow reactor

With raney nickel; In methanol; diethyl ether; dibutyl ether;
DOI:10.1055/s-0036-1588313