914801-74-4

Upstream product

• 395-01-7 2,2-difluoro-1-phenylethanone 
• 75-31-0 isopropylamine 
• 173603-23-1 (E)-2,2′-(1-phenylethene-1,2-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) 

Downstream Products

• 1039364-51-6 N-((1E)-5-chloro-2,2-difluoro-1-phenylpentylidene)isopropylamine 
• 1039364-55-0 N-((1E)-5-azido-2,2-difluoro-1-phenylpentylidene)isopropylamine 
• 951408-28-9 5,5-difluoro-6-phenyl-2,3,4,5-tetrahydropyridine 

Relevant academic research and scientific papers

New entries toward 3,3-difluoropiperidines

(Chemical Equation Presented) Difluoropiperidines attract considerable interest from organic and medicinal chemists, but their synthesis is often problematic. This paper describes a new synthetic pathway toward valuable 3,3-difluoropiperidines starting fr

One-pot synthesis of α,α-difluoroimines from alkynes through tandem catalytic diboration/fluorination/imination reaction

Tandem catalytic diboration/fluorination/imination of arylacetylenes leads to the formation of α,α-difluoroimines, where the adjacent C{double bond, long}N and C-F2 bonds are formed simultaneously. The convenient one-pot protocol involves a Pt(0)-catalyzed diboration of terminal or internal arylalkynes followed by electrophilic fluorination with Selectfluor in the presence of primary amines and a dehydrating agent. A plausible mechanism for the three consecutive steps (diboration/fluorination/imination) is suggested in accordance with the electronic properties of the substrates. Alkynes/catalytic diboration/alkenyl diboronate esters/Selectfluor/electrophilic fluorination/α,α-difluoroimines.