tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate

Base Information

Chemical Name:tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate
CAS No.:1316756-58-7
Molecular Formula:C₁₈H₂₂F₃NO₃
Molecular Weight:357.373
Hs Code.:

Synonyms:tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate

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Chemical Property of tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate

Chemical Property:

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Technology Process of tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate

There total 1 articles about tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 455330-42-4
4R-(4-oxocyclohex-2-enyl)carbamic acid tert-butyl ester

: 1316756-58-7
tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate

Guidance literature:: 4-(trifluoromethyl)phenylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -78 ℃; for 1.5h;

4R-(4-oxocyclohex-2-enyl)carbamic acid tert-butyl ester; In tetrahydrofuran; for 0.166667h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield: 75.0%

: 1316756-58-7
tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate

: 1316756-59-8
tert-butyl {(1R,2S,4S)-4-hydroxy-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate

Guidance literature:: tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate; With L-Selectride; In tetrahydrofuran; at -78 - 20 ℃; for 18h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 1316756-58-7
tert-butyl {(1R,2S)-4-oxo-2-[4-(trifluoromethyl)phenyl]cyclohexyl}carbamate

: 1316756-97-4
methyl {(1R,3S,4R)-4-[benzyl(cyclopentylmethyl)amino]-3-[4-(trifluoromethyl)phenyl]cyclohexyl}acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: L-Selectride / tetrahydrofuran / 18 h / -78 - 20 °C

2.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

3.1: sodium hydride / 1,2-dimethoxyethane / 2 h / 20 °C

3.2: 36 h / Reflux

4.1: hydrogenchloride; water / 72 h / Reflux

4.2: 1 h / Reflux

5.1: methanol / 4 h / 20 °C

5.2: 0 °C

6.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 4 h / 0 - 20 °C

With hydrogenchloride; water; L-Selectride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;