tert-Butyl 4-(3-bromobenzylamino)piperidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 4-(3-bromobenzylamino)piperidine-1-carboxylate
CAS No.:359877-98-8
Molecular Formula:C17H25 Br N2 O2
Molecular Weight:369.302
Hs Code.:2933399090
DSSTox Substance ID:DTXSID10469543
Wikidata:Q82297324
Mol file:359877-98-8.mol

Synonyms:359877-98-8;tert-Butyl 4-(3-bromobenzylamino)piperidine-1-carboxylate;tert-Butyl 4-((3-bromobenzyl)amino)piperidine-1-carboxylate;Tert-butyl 4-[(3-bromophenyl)methylamino]piperidine-1-carboxylate;SCHEMBL4210228;DTXSID10469543;VUVQLTINLBNMJM-UHFFFAOYSA-N;AKOS027378993;KS-5870;1-Piperidinecarboxylicacid, 4-[[(3-bromophenyl)methyl]amino]-, 1,1-dimethylethyl ester;CS-0362677;3-(1,3-Benzodioxol-5-yl)-2-cyanoacrylicacid;tert-Butyl4-((3-bromobenzyl)amino)piperidine-1-carboxylate;tert-butyl 4-((3-bromophenyl)methyl)amino-piperidine carboxylate;TERT-BUTYL 4-{[(3-BROMOPHENYL)METHYL]AMINO}PIPERIDINE-1-CARBOXYLATE

Suppliers and Price of tert-Butyl 4-(3-bromobenzylamino)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
1-Boc-4-(3-Bromo-benzylamino)-piperidine 95
10g
$ 2567.00

Labseeker
1-Boc-4-(3-Bromo-benzylamino)-piperidine 95
5g
$ 1833.00

Crysdot
tert-Butyl4-((3-bromobenzyl)amino)piperidine-1-carboxylate 97%
1g
$ 309.00

American Custom Chemicals Corporation
1-BOC-4-(3-BROMO-BENZYLAMINO)-PIPERIDINE 95.00%
5MG
$ 504.49

Total 3 raw suppliers

Chemical Property of tert-Butyl 4-(3-bromobenzylamino)piperidine-1-carboxylate

Chemical Property:

PSA：41.57000
LogP:4.26700
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:368.10994
Heavy Atom Count:22
Complexity:362

Purity/Quality:

99% ^*data from raw suppliers

1-Boc-4-(3-Bromo-benzylamino)-piperidine 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)NCC2=CC(=CC=C2)Br

Technology Process of tert-Butyl 4-(3-bromobenzylamino)piperidine-1-carboxylate

There total 9 articles about tert-Butyl 4-(3-bromobenzylamino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-bromobenzylamine hydrobromide

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 359877-98-8
tert-butyl 4-((3-bromophenyl)methyl)aminopiperidine carboxylate

Guidance literature:: With sodium hydroxide; NaCNBH₃; acetic acid; In methanol; diethyl ether; water;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 359877-98-8
tert-butyl 4-((3-bromophenyl)methyl)aminopiperidine carboxylate

Guidance literature:: m-bromobenzoic aldehyde; 1-(tert-butoxycarbonyl)-4-aminopiperidine; In methanol; for 4h; Heating / reflux;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h; Heating / reflux;

Reference yield:

: 13035-19-3
4-aminopiperidine

: 359877-98-8
tert-butyl 4-((3-bromophenyl)methyl)aminopiperidine carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 5.5 h / Inert atmosphere; Reflux

2: toluene / 14.08 h / 0 - 20 °C / Inert atmosphere

3: potassium hydrogensulfate; water / tert-butyl methyl ether / 4 h / 20 °C / Inert atmosphere

4: magnesium sulfate; sodium tetrahydroborate / ethanol / 22 h / 20 - 70 °C / Inert atmosphere

With sodium tetrahydroborate; potassium hydrogensulfate; water; magnesium sulfate; In ethanol; tert-butyl methyl ether; toluene;
DOI:10.1016/j.bmc.2012.08.026