N-(2-(3-cyclopropyl-1-hydroxyprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(2-(3-cyclopropyl-1-hydroxyprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide
CAS No.:1394401-59-2
Molecular Formula:C₁₉H₁₉NO₃S
Molecular Weight:341.431
Hs Code.:

Synonyms:N-(2-(3-cyclopropyl-1-hydroxyprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide

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Chemical Property of N-(2-(3-cyclopropyl-1-hydroxyprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-(2-(3-cyclopropyl-1-hydroxyprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide

There total 6 articles about N-(2-(3-cyclopropyl-1-hydroxyprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6590-65-4
N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide

: 6746-94-7
Cyclopropylacetylene

: 1394401-59-2
N-(2-(3-cyclopropyl-1-hydroxyprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide

Guidance literature:: N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; cyclohexane; at -20 ℃; for 0.166667h; under 760.051 Torr;

Cyclopropylacetylene; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; under 760.051 Torr;
DOI:10.1021/jo301198z

Reference yield:

: 529-23-7
o-aminobenzaldehyde

: 1394401-59-2
N-(2-(3-cyclopropyl-1-hydroxyprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 4 h / 20 °C / 760.05 Torr / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; cyclohexane / 0.17 h / -20 °C / 760.05 Torr

2.2: 1 h / -78 °C / 760.05 Torr

With pyridine; n-butyllithium; diisopropylamine; In tetrahydrofuran; cyclohexane;
DOI:10.1021/jo301198z

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1394401-59-2
N-(2-(3-cyclopropyl-1-hydroxyprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.17 h / -78 - -40 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/adsc.202100572