1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine

Base Information

Chemical Name:1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine
CAS No.:1026583-69-6
Molecular Formula:C₂₃H₂₆F₃NO₃
Molecular Weight:421.46
Hs Code.:

Synonyms:1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine

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Chemical Property of 1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine

Chemical Property:

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Technology Process of 1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine

There total 1 articles about 1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28033-37-6
4-[4-(trifluoromethyl)-phenoxy]piperidine

: 36603-49-3
4-(tetrahydropyran-2'-yloxy)-1-bromobenzene

: 1026583-69-6
1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine

Guidance literature:: With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 0.5h; Heating;
DOI:10.1021/jm060957y

Reference yield:

: 1026583-69-6
1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine

: 681509-01-3
4-[4-(4-trifluoromethylphenoxy)piperidin-1-yl]phenol

Guidance literature:: With ethanol; pyridinium p-toluenesulfonate; at 70 ℃; for 24h;
DOI:10.1021/jm060957y

Reference yield:

: 1026583-69-6
1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine

: 2-methyl-6-nitro-2-{4-[4-(4-trifluoromethyl-phenoxy)-piperidin-1-yl]-phenoxymethyl}-2,3-dihydro-imidazo[2,1-b]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: EtOH / pyridinium p-toluenesulfonate / 24 h / 70 °C

2: NaH / dimethylformamide / 2 h / 50 °C

With ethanol; sodium hydride; pyridinium p-toluenesulfonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm060957y