Technology Process of 2-Pyrrolidinone, 1,3,3-trimethyl-
There total 14 articles about 2-Pyrrolidinone, 1,3,3-trimethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-bromomethyl-1,3-dimethyl-pyrrolidin-2-one;
With
tert.-butyl lithium;
In
pentane;
at -45 ℃;
for 2h;
With
water;
In
pentane;
at -45 - 20 ℃;
for 0.5h;
DOI:10.1055/s-2003-42045
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
benzene;
for 2h;
Heating;
DOI:10.3987/COM-93-6465
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium chloride; lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
2.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: dichloromethane / 2 h / Inert atmosphere
4.1: sodium hydroxide / 1,4-dioxane; water / pH 12 / Inert atmosphere
4.2: Inert atmosphere
4.3: Inert atmosphere
5.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h / Inert atmosphere
5.2: Inert atmosphere
6.1: dichloromethane / 2 h / Inert atmosphere
7.1: water; isopropyl alcohol / 37 °C / pH 7.4 / aq. phosphate buffer
With
1-chloro-1-(dimethylamino)-2-methyl-1-propene; lithium chloride; sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; isopropyl alcohol;
DOI:10.1039/c0ob00890g
