(3S)-3,4-dihydro-2-methoxy-N-methyl-3-phenylmethyl-[1,4]benzodiazepin-5(5H)one

Base Information

Chemical Name:(3S)-3,4-dihydro-2-methoxy-N-methyl-3-phenylmethyl-[1,4]benzodiazepin-5(5H)one
CAS No.:211567-41-8
Molecular Formula:C₁₈H₁₈N₂O₂
Molecular Weight:294.353
Hs Code.:

Synonyms:(3S)-3,4-dihydro-2-methoxy-N-methyl-3-phenylmethyl-[1,4]benzodiazepin-5(5H)one

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Chemical Property of (3S)-3,4-dihydro-2-methoxy-N-methyl-3-phenylmethyl-[1,4]benzodiazepin-5(5H)one

Chemical Property:

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Technology Process of (3S)-3,4-dihydro-2-methoxy-N-methyl-3-phenylmethyl-[1,4]benzodiazepin-5(5H)one

There total 5 articles about (3S)-3,4-dihydro-2-methoxy-N-methyl-3-phenylmethyl-[1,4]benzodiazepin-5(5H)one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 196928-07-1
N-(2-azidobenzoyl)-N-methyl-L-phenylalanine methyl ester

: 211567-41-8
(3S)-3,4-dihydro-2-methoxy-N-methyl-3-phenylmethyl-[1,4]benzodiazepin-5(5H)one

Guidance literature:: With tributylphosphine; In toluene; at 20 ℃; for 7.5h; Heating;
DOI:10.1016/S0040-4020(98)00437-2

Reference yield:

: 34897-85-3
o-azidobenzoyl chloride

: 211567-41-8
(3S)-3,4-dihydro-2-methoxy-N-methyl-3-phenylmethyl-[1,4]benzodiazepin-5(5H)one

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Et₃N / tetrahydrofuran / 16 h / 0 - 20 °C

2: n-Bu₃P / toluene / 7.5 h / 20 °C / Heating

With tributylphosphine; triethylamine; In tetrahydrofuran; toluene; 1: Acylation / 2: Cyclization;
DOI:10.1016/S0040-4020(98)00437-2

Reference yield:

: 31162-13-7
2-azidobenzoic acid

: 211567-41-8
(3S)-3,4-dihydro-2-methoxy-N-methyl-3-phenylmethyl-[1,4]benzodiazepin-5(5H)one

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / tetrahydrofuran / 2 h / 80 °C

2: 94 percent / Et₃N / tetrahydrofuran / 16 h / 0 - 20 °C

3: n-Bu₃P / toluene / 7.5 h / 20 °C / Heating

With thionyl chloride; tributylphosphine; triethylamine; In tetrahydrofuran; toluene; 1: Substitution / 2: Acylation / 3: Cyclization;
DOI:10.1016/S0040-4020(98)00437-2