benzomalvin A

Base Information

Chemical Name:benzomalvin A
CAS No.:157047-96-6
Molecular Formula:C₂₄H₁₉N₃O₂
Molecular Weight:381.434
Hs Code.:
Mol file:157047-96-6.mol

Synonyms:benzomalvin A

Suppliers and Price of benzomalvin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
Benzomalvin A ≥95%
1mg
$ 275.00

Cayman Chemical
Benzomalvin A ≥95%
5mg
$ 650.00

AK Scientific
7-Benzyl-6-methyl-6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione
1mg
$ 471.00

Total 3 raw suppliers

Chemical Property of benzomalvin A

Chemical Property:

Vapor Pressure:2.53E-14mmHg at 25°C
Boiling Point:599.3°Cat760mmHg
PKA:-0.46±0.40(Predicted)
Flash Point:316.3°C
Density:1.28g/cm³

Purity/Quality:

≥95% ^*data from raw suppliers

Benzomalvin A ≥95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Benzomalvin A is a fungal metabolite produced by Penicillium. It inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM). In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 μM, respectively).

Technology Process of benzomalvin A

There total 12 articles about benzomalvin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 7-benzyl-6,7-dihydro-6,8,13a-triaza-benzo[3,4]cyclohepta[1,2-b]naphthalene-5,13-dione

: 74-88-4
methyl iodide

: 157047-96-6
(+/-)-benzomalvin A

: 7-benzyl-5-methoxy-7H-6,8,13a-triaza-benzo[3,4]cyclohepta[1,2-b]naphthalen-13-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo051876x

Reference yield:

: 4530-18-1
2-(tert-butoxycarbonylamino)-3-phenylpropionic acid

: 157047-96-6
(+/-)-benzomalvin A

Guidance literature:: Multi-step reaction with 2 steps

1: triphenyl phosphite; pyridine / 0.33 h / 230 °C / microwave irradiation

2: 70 percent / LiHMDS / tetrahydrofuran / -78 - 20 °C

With pyridine; triphenyl phosphite; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jo051876x

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 157047-96-6
(+/-)-benzomalvin A

Guidance literature:: Multi-step reaction with 2 steps

1: triphenyl phosphite; pyridine / 0.33 h / 230 °C / microwave irradiation

2: 70 percent / LiHMDS / tetrahydrofuran / -78 - 20 °C

With pyridine; triphenyl phosphite; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jo051876x