3-{(E)-2-[2-(2-Piperidin-1-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride

Base Information

Chemical Name:3-{(E)-2-[2-(2-Piperidin-1-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride
CAS No.:88137-15-9
Molecular Formula:C₂₂H₂₄N₂O₂*ClH
Molecular Weight:384.906
Hs Code.:

Synonyms:3-{(E)-2-[2-(2-Piperidin-1-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-{(E)-2-[2-(2-Piperidin-1-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride

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Technology Process of 3-{(E)-2-[2-(2-Piperidin-1-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride

There total 2 articles about 3-{(E)-2-[2-(2-Piperidin-1-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 88137-14-8
3-(triphenylphosphoniummethyl)-1,2-benzisoxazole bromide

: 14573-94-5
2-(2-Piperidin-1-yl-ethoxy)-benzaldehyde

: 88137-15-9
3-{(E)-2-[2-(2-Piperidin-1-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1248/cpb.31.2023

Reference yield:

: 37924-85-9
3-bromomethyl-1,2-benzisoxazole

: 88137-15-9
3-{(E)-2-[2-(2-Piperidin-1-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / toluene / 8 h / 90 °C

2: 41 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature

With sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1248/cpb.31.2023