37924-85-9

Basic information

• Product Name: 3-(BROMOMETHYL)-1,2-BENZISOXAZOLE
• Synonyms: BMBI;3-(BROMOMETHYL)-1,2-BENZISOXAZOLE;3-BROMOMETHYL-1,2-BENZISOXAZOLE(ZONISAMIDE INTERMEDIATE);3-Bromoethylbenzo[o]isoxazole;3-(bromomethyl)benzo[d]isoxazole;1,2-Benzisoxazole, 3-(bromomethyl)-;3-Bromomethylbenzisoxazole
• CAS NO: 37924-85-9
• Molecular Formula: C₈H₆BrNO
• Molecular Weight: 212.04
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles
• Mol File: 37924-85-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 64-65°C
• Boiling Point: 302.5 °C at 760 mmHg
• Flash Point: 136.8 °C
• Appearance: colourless crystalline solid
• Density: 1.642 g/cm³
• Vapor Pressure: 0.00176mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Acetone, Chloroform, Dichloromethane, Ethyl Acetate
• PKA: -3.26±0.30(Predicted)
• CAS DataBase Reference: 3-(BROMOMETHYL)-1,2-BENZISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(BROMOMETHYL)-1,2-BENZISOXAZOLE(37924-85-9)
• EPA Substance Registry System: 3-(BROMOMETHYL)-1,2-BENZISOXAZOLE(37924-85-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 37924-85-9(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Crystalline Solid

InChI:InChI=1/C8H6BrNO/c9-5-7-6-3-1-2-4-8(6)11-10-7/h1-4H,5H2

Upstream product

• 4865-84-3 2-(benzo[d]isoxazol-3-yl)acetic acid 
• 22105-09-5 4‐hydroxycoumarin 
• 118-93-4 o-hydroxyacetophenone 
• 21895-22-7 2’-hydroxyacetophenone imine 
• 37924-67-7 α-bromo-1,2-benzisoxazole-3-acetic acid 
• 4825-75-6 3-methylbenzo[d]isoxazole 
• 2491-36-3 2-(2-bromoacetyl)hydroxybenzene 

Downstream Products

• 37925-02-3 acetylamino-benzo[d]isoxazol-3-ylmethyl-malonic acid diethyl ester 
• 867040-03-7 3-ethoxymethyl-1,2-benzisoxazole 
• 73101-64-1 1,2-benzisoxazole-3-methanesulfonic acid sodium salt 
• 869885-63-2 3-Bromomethyl-benzo[d]isoxazole-5-sulfonyl chloride 
• 1607024-45-2 2-(benzo[d]isoxazol-3-yl)-3-(dimethylamino)acrylonitrile 
• 1607024-46-3 4-(benzo[d]isoxazol-3-yl)-1H-pyrazol-5-amine 
• 1607023-00-6 3-(benzo[d]isoxazol-3-yl)-5-(4-chloro-3-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-09-5 3-(benzo[d]isoxazol-3-yl)-5-(1-ethyl-1H-indazol-5-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-10-8 3-(benzo[d]isoxazol-3-yl)-5-(3,4-dichlorophenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-11-9 3-(benzo[d]isoxazol-3-yl)-5-(4-chloro-3-ethoxyphenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 50471-17-5 2-(benzo[d]isoxazol-3-yl)acetonitrile 
• 37924-88-2 3-bromomethyl-5-nitro-benzo[d]isoxazole 
• 155204-08-3 C-benzo[d]isoxazol-3-yl-methylamine 

Relevant articles and documents

Benzisoxazole heterocyclic compound as well as preparation method and application thereof

The invention relates to a benzisoxazole heterocyclic compound and a preparation method and application thereof, and the structural formula comprises the formula (I). (II), (III), and particularly provides a specific preparation method of the compound. The derivative has good anticonvulsant activity and can be used as an anti-epileptic drug.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

A new method for the preparation of 1,2-benzisoxazole-3-carboxaldehyde

Synthesis of 1,2-benzisoxazole-3-carboxaldehyde is achieved from 3-methyl 1,2-benzisoxazole via 3-ethoxymethyl-1,2-benzisoxazole (4).