methyl 4-(5-((S)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

Base Information

Chemical Name:methyl 4-(5-((S)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate
CAS No.:1187649-71-3
Molecular Formula:C₂₀H₁₉ClN₄O₂
Molecular Weight:382.849
Hs Code.:

Synonyms:methyl 4-(5-((S)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

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Chemical Property of methyl 4-(5-((S)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

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Technology Process of methyl 4-(5-((S)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

There total 4 articles about methyl 4-(5-((S)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 4-(5-(1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate trifluoroacetate

: 1187649-73-5
methyl 4-(5-((R)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

: 1187649-71-3
methyl 4-(5-((S)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

Guidance literature:: With CHIRALCEL OD; 2,2'-iminobis[ethanol]; In methanol; ethanol; n-heptane; Resolution of racemate;

Reference yield:

: 5123-55-7
Nα-phthaloyl-L-phenylalanine

: 1187649-73-5
methyl 4-(5-((R)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

: 1187649-71-3
methyl 4-(5-((S)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium peroxydisulfate; silver nitrate; trifluoroacetic acid / water / 0.83 h / 70 °C

2: potassium phosphate / triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

3: hydrazine / ethanol / 4 h / 80 °C

4: CHIRALCEL OD; 2,2'-iminobis[ethanol] / methanol; ethanol; n-heptane / Resolution of racemate

With ammonium peroxydisulfate; potassium phosphate; CHIRALCEL OD; silver nitrate; 2,2'-iminobis[ethanol]; trifluoroacetic acid; hydrazine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; n-heptane; water; 2: Suzuki Coupling;

Reference yield:

: 1187648-11-8
2-(1-(3,6-dichloropyridazin-4-yl)-2-phenylethyl)isoindoline-1,3-dione

: 1187649-73-5
methyl 4-(5-((R)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

: 1187649-71-3
methyl 4-(5-((S)-1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2: hydrazine / ethanol / 4 h / 80 °C

3: CHIRALCEL OD; 2,2'-iminobis[ethanol] / methanol; ethanol; n-heptane / Resolution of racemate

With potassium phosphate; CHIRALCEL OD; 2,2'-iminobis[ethanol]; hydrazine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; n-heptane; 1: Suzuki Coupling;